Chapter 1. Requiem of the Wraith

Difficulty 1: Chronol, TT1-1 (TT60), 60+
There are 3 more bosses in High Settings but they don't drop any TT mats for TT60 so don't waste your ultimate substance by selecting High Boss settings.

But, for Quest Wraith's Ploy you must go 1-1 high to complete it. This will be the only time you will have to use an ultimate Substance in 1-1

According to the PW Database the higher settings increase the percentage of the mat drops. So for Broken Drum it would be about 42.1297% in Low and 91.2208% in the high end setting.

Difficulty 3: Substancia, TT1-3 (TT80), 76+

 * in single mode need 2 substance